The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 13, 2005
Filed:
Oct. 02, 1998
Roger J. Davis, Princeton, MA (US);
Richard A. Flavell, Guilford, CT (US);
Pasko Rakic, New Haven, CT (US);
Alan J. Whitmarsh, Shrewsbury, MA (US);
Chia-yi Kuan, Wallingford, CT (US);
Derek Di Yang, Carmel, IN (US);
Roger J. Davis, Princeton, MA (US);
Richard A. Flavell, Guilford, CT (US);
Pasko Rakic, New Haven, CT (US);
Alan J. Whitmarsh, Shrewsbury, MA (US);
Chia-Yi Kuan, Wallingford, CT (US);
Derek Di Yang, Carmel, IN (US);
University of Massachusetts, Boston, MA (US);
Yale University, New Haven, CT (US);
Abstract
The c-Jun NH-terminal kinase (JNK) group of MAP kinases are activated by exposure of cells to environmental stress. The role of JNK in the brain was examined by targeted disruption of the gene that encodes the neuronal isoform JNK3. It was found that JNK3 is required for the normal response to seizure activity. Methods of screening for molecules and compounds that decrease JNK3 expression or activity are described. Such molecules or compounds are useful for treating disorders involving excitotoxicity such as seizure disorders, Alzheimer's disease, Huntington disease, Parkinson's disease, and ischaemia.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile