The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 06, 2005
Filed:
Dec. 17, 2003
Vivekananda M. Vrudhula, Killingworth, CT (US);
Valentin Kala Gribkoff, Wallingford, CT (US);
Bireshwar Dasgupta, Middletown, CT (US);
Christopher G. Boissard, Northford, CT (US);
Vivekananda M. Vrudhula, Killingworth, CT (US);
Valentin Kala Gribkoff, Wallingford, CT (US);
Bireshwar Dasgupta, Middletown, CT (US);
Christopher G. Boissard, Northford, CT (US);
Bristol-Myers Squibb Company, Princeton, NJ (US);
Abstract
Atropisomers of 3-substituted-4-arylquinolin-2-one derivatives having the general formulawherein R, R, R, R, Rand R, are as defined herein, or a non-toxic pharmaceutically acceptable salt, solvate or prodrug thereof. The atropisomers can modulate the large conductance calcium-activated Kchannels and are useful in the treatment of disorders which are responsive to the opening of the potassium channels. In addition, the atropisomers can be stable, i.e., do not interconvert, for periods of up to one month, or more.