The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 06, 2005
Filed:
Jun. 24, 2004
Louis S. Crocker, Belle Mead, NJ (US);
Joseph L. Kukura, Ii, Somerset, NJ (US);
Andrew S. Thompson, Mountainside, NJ (US);
Christine Stelmach, Westfield, NJ (US);
Steven D. Young, Lansdale, PA (US);
Louis S. Crocker, Belle Mead, NJ (US);
Joseph L. Kukura, II, Somerset, NJ (US);
Andrew S. Thompson, Mountainside, NJ (US);
Christine Stelmach, Westfield, NJ (US);
Steven D. Young, Lansdale, PA (US);
Merck & Co., Inc., Rahway, NJ (US);
Abstract
The instant invention describes a method for crystallizing (−)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one from a solvent and anti-solvent solvent system and producing the crystalline product. The desired final crystal form, Form I, can be produced when using methanol or ethanol. Form II is isolated from 2-propanol and can be converted to the desired crystal form at low drying temperatures, such as between about a temperature of 40° C. and 50° C.