The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 06, 2005
Filed:
Sep. 30, 2003
Peter Stanley Borromeo, Fishers, IN (US);
Jeffrey Daniel Cohen, Indianapolis, IN (US);
George Stuart Gregory, Fishers, IN (US);
Stacy Kay Henle, Indianapolis, IN (US);
Stephen Andrew Hitchcock, Carmel, IN (US);
Louis Nickolaus Jungheim, Indianapolis, IN (US);
Daniel Ray Mayhugh, Carmel, IN (US);
Timothy Alan Shepherd, Indianapolis, IN (US);
William Wilson Turner, Jr., Bloomington, IN (US);
Peter Stanley Borromeo, Fishers, IN (US);
Jeffrey Daniel Cohen, Indianapolis, IN (US);
George Stuart Gregory, Fishers, IN (US);
Stacy Kay Henle, Indianapolis, IN (US);
Stephen Andrew Hitchcock, Carmel, IN (US);
Louis Nickolaus Jungheim, Indianapolis, IN (US);
Daniel Ray Mayhugh, Carmel, IN (US);
Timothy Alan Shepherd, Indianapolis, IN (US);
William Wilson Turner, Jr., Bloomington, IN (US);
Eli Lilly and Company, Indianapolis, IN (US);
Abstract
A method for modifying the cyclic peptide ring system of Echinocandin-type compounds to produce new analogs having antifungal activity is provided. The inventive process comprises opening the cyclic peptide ring, cleaving the terminal ornithine unit, inserting at least one new amino acid or other synthetic unit and closing the ring to produce a new cyclic peptide ring structure. The process allows one to incorporate features such as water-solubility into the cyclic peptide ring nucleus, sites for further modification, increase or decrease the number of amino acid or peptide units within the ring nucleus, and increase or decrease the total number of members within the ring. The invention further provides novel Echinocandin type compounds and their use as antifungal or anti-parasitic agents.