The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 06, 2005
Filed:
Jul. 31, 2000
Ronald G. Crystal, Potomac, MD (US);
Chisa Hidaka, New York, NY (US);
Oheneba Boachie-adjei, New York, NY (US);
Bernard A. Rawlins, Englewood, NJ (US);
Imre Kovesdi, Rockville, MD (US);
Ronald G. Crystal, Potomac, MD (US);
Chisa Hidaka, New York, NY (US);
Oheneba Boachie-Adjei, New York, NY (US);
Bernard A. Rawlins, Englewood, NJ (US);
Imre Kovesdi, Rockville, MD (US);
Cornell Research Foundation, Inc., Ithaca, NY (US);
The Hospital for Special Surgery, New York, NY (US);
GenVec, Inc., Gaithersburg, MD (US);
Abstract
The present invention is directed to a method for enhancing bone density or formation. In accordance with the method, a nucleic acid encoding an angiogenic protein is administered to a cell in a region of a bone such that the nucleic acid is expressed to produce the angiogenic protein, whereby bone density or formation is enhanced within the region. Optionally, a nucleic acid encoding an osteogenic protein is administered to a cell within the same region such that the nucleic acid is expressed to produce the osteogenic protein. The method can be employed to produce a bone graft having a cell harboring an exogenous nucleic acid encoding an angiogenic protein and, optionally, a cell harboring a nucleic acid encoding an osteogenic protein. To facilitate the inventive method, the invention also pertains to a recombinant viral vector having a nucleic acid encoding an angiogenic protein and a nucleic acid encoding an osteogenic protein.