The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 30, 2005
Filed:
Feb. 24, 2003
Marioara Mendelovici, Rechovot, IL;
Neomi Gershon, Kfar-Saba, IL;
Tamar Nidam, Yehud, IL;
Gideon Pilarski, Holon, IL;
Greta Sterinbaum, Rishon-Lezion, IL;
Marioara Mendelovici, Rechovot, IL;
Neomi Gershon, Kfar-Saba, IL;
Tamar Nidam, Yehud, IL;
Gideon Pilarski, Holon, IL;
Greta Sterinbaum, Rishon-Lezion, IL;
Teva Pharmaceutical Industries Ltd., Petah Tiqva, IL;
Abstract
The present invention relates to a process of preparing benzisoxazole methane sulfonic acid-chloride (BOS—Cl) as an zonisamide intermediate via chlorination of benzisoxazole methane sulfonate. The present invention also discloses a process of preparing zonisamide via amidation of BOS—Cl. More particularly, the present invention provides a process of preparing zonisamide, comprising the steps of: a) chlorinating BOS, salts or esters thereof, with SOClin an organic solvent and/or in the presence of a catalyst to form BOS—Cl; and b) amidating BOS—Cl in the presence of ammonia selected from the group consisting of aqueous ammonia in a biphasic system, masked ammonia and dry ammonia to form zonisamide.