The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 30, 2005
Filed:
Oct. 29, 2002
David S. Garvey, Dover, MA (US);
L. Gordon Letts, Dover, MA (US);
Chia-en Lin, Burlington, MA (US);
Tiansheng Wang, Concord, MA (US);
David S. Garvey, Dover, MA (US);
L. Gordon Letts, Dover, MA (US);
Chia-En Lin, Burlington, MA (US);
Tiansheng Wang, Concord, MA (US);
NitroMed, Inc., Lexington, MA (US);
Abstract
The invention describes novel nitrosated and/or nitrosylated Hreceptor antagonist compounds, and novel compositions comprising at least one Hreceptor antagonist compound that is optionally substituted with at least one NO and/or NOgroup, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase and/or at least one nonsteroidal antiinflammatory drug, antacid, bismuth-containing reagent or anti-viral agent. The invention also describes methods for treating and/or preventing gastrointestinal disorders; improving gastroprotective properties of Hreceptor antagonists; decreasing the recurrence of ulcers; facilitating ulcer healing; preventing and/or treating inflammations and microbial infections, ophthalmic diseases and disorders, multiple sclerosis, and viral infections; and decreasing or reducing the gastrointestinal toxicity associated with the use of nonsteroidal antiinflammatory compounds.