The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 23, 2005
Filed:
Feb. 25, 2002
Man Sung CO, Cupertino, CA (US);
David A. Scheinberg, New York, NY (US);
Cary L. Queen, Los Altos, CA (US);
Man Sung Co, Cupertino, CA (US);
David A. Scheinberg, New York, NY (US);
Cary L. Queen, Los Altos, CA (US);
Protein Design Labs, Inc., Fremont, CA (US);
Memorial Sloan Kettering Cancer Center, New York, NY (US);
Abstract
The present invention provides methods for producing mutationally-altered immunoglobulins and compositions containing such mutationally-altered immunoglobulins, wherein the mutationally-altered immunoglobulins have at least one mutation that alters the pattern of glycosylation in a variable region and thereby modifies the affinity of the immunoglobulin for a preselected antigen. The methods and compositions of the invention provide immunoglobulins that possess increased affinity for antigen. Such glycosylation-altered immunoglobulins are suitable for diagnostic and therapeutic applications.