The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 23, 2005
Filed:
Nov. 29, 2001
Kim Vilbour Andersen, Broenshoej, DK;
Anders Hjelholt Pedersen, Lyngby, DK;
Per Ola Freskgaard, Vellinge, SE;
Kim Vilbour Andersen, Broenshoej, DK;
Anders Hjelholt Pedersen, Lyngby, DK;
Per Ola Freskgaard, Vellinge, SE;
Maxygen Aps, Hoersholm, DK;
Maxygen Holdings, Ltd., Grand Cayman, KY;
Abstract
The present invention relates to novel conjugates between polypeptide variants of protein C and a non-polypeptide moiety, such as PEG or sugar moieties. In particular, the present invention provides novel protein C conjugates having an increased resistance to inactivation by e.g. human plasma and α-antitrypsin. Consequently, such conjugates have an increased in vivo half-life. Preferred examples include protein C conjugates, wherein at least one additional in vivo N-glycosylation site has been introduced. The conjugates of the invention are useful for treating a variety of diseases, including septic shock.