The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 23, 2005
Filed:
Aug. 14, 2001
R. Martin Emanuele, Alpharetta, GA (US);
Mark Newman, Carlsbad, CA (US);
Konstantin G. Kousoulas, Baton Rouge, LA (US);
Hameedsulthan S. Allaudeen, Durham, NC (US);
R. Martin Emanuele, Alpharetta, GA (US);
Mark Newman, Carlsbad, CA (US);
Konstantin G. Kousoulas, Baton Rouge, LA (US);
Hameedsulthan S. Allaudeen, Durham, NC (US);
Other;
Abstract
The present invention relates to compositions and methods for treating infectious diseases and genetic disorders through gene therapy and intracellular delivery of antisense oligonucleotides or other nucleic acid sequences. In particular, compositions and methods using biologically active nononic reverse block copolymers are described. The reverse copolymers have an inner core of polyoxyethylene (POE) that is flanked on either end by polyoxpropylene (POP). The reverse block copolymers have the following formula:wherein 'b' represents a number such that the molecular weight of the hydrophobe (CHO)is between approximately 750 and 20,000 Daltons and 'a' represents a number such that the percentage of hydrophile (CHO)is between approximately 1% and 90% of the weight of the block copolymer.