The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 16, 2005
Filed:
Mar. 31, 2000
Thomas S. Kupper, Weston, MA (US);
Ulrich Von Andrian, Boston, MA (US);
Caroline Robert, Sceaux, FR;
Thomas S. Kupper, Weston, MA (US);
Ulrich Von Andrian, Boston, MA (US);
Caroline Robert, Sceaux, FR;
The Brigham & Women's Hospital, Inc., Boston, MA (US);
The CBR Institute for Biomedical Research, Inc., Boston, MA (US);
Abstract
The invention provides isolated dendritic cells genetically modified to express a selectin polypeptide, optionally treated with activated platelets or membrane microparticles thereof. The invention also provides isolated platelet modified dendritic cells. Methods for delivering the modified dendritic cells to peripheral lymph nodes and methods for using the modified dendritic cells to stimulate immune responses also are provided. Vaccine compositions containing the modified dendritic cells also are provided.