The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 09, 2005
Filed:
Jun. 11, 2002
Mark A. Gallop, Los Altos, CA (US);
Jia-ning Xiang, Palo Alto, CA (US);
Fenmei Yao, Mountain View, CA (US);
Laxminarayan Bhat, Santa Clara, CA (US);
Cindy X. Zhou, Palo Alto, CA (US);
Mark A. Gallop, Los Altos, CA (US);
Jia-Ning Xiang, Palo Alto, CA (US);
Fenmei Yao, Mountain View, CA (US);
Laxminarayan Bhat, Santa Clara, CA (US);
Cindy X. Zhou, Palo Alto, CA (US);
Xero Port, Inc., Santa Clara, CA (US);
Abstract
Disclosed is a method for synthesizing 1-(acyloxy)-alkyl derivatives of primary or secondary amine drugs from 1-acyl-alkyl derivatives of primary or secondary amine drugs, which typically proceeds stereospecifically, in high yield, does not require the use of activated intermediates and/or toxic compounds and is readily amenable to scale-up. For example, 1-acyl-alkyl derivatives of gabapentin and pregabalin are oxidized to yield 1-(acyloxy)-alkyl derivatives of gabapentin and pregabalin, respectively.