The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 09, 2005
Filed:
Jun. 28, 2000
Mary M. Dyszlewski, Creve Coeur, MO (US);
Roger Alberto, Winterthur, CH;
Joseph E. Bugaj, St. Charles, MO (US);
Mary M. Dyszlewski, Creve Coeur, MO (US);
Roger Alberto, Winterthur, CH;
Joseph E. Bugaj, St. Charles, MO (US);
Mallinckrodt Inc, St. Louis, MO (US);
Abstract
The invention relates to novel aminocarboxylate ligands that are suitable for complexing with a radionuclide, and are useful as imaging agents for diagnostic purposes. In accordance with the present invention, a method of preparing a compound of formula (I): fac-[M(CO)(OH)], wherein M is Mn,Tc,Re orRe, involves reacting a metal in permetallate form with carbon monoxide and a reducing agent, wherein a mixture of a basic borate buffer and a reducing agent soluble in water but not substantially decomposed by water is solved in a water containing solvent system containing a solution of the metal in permanganate, pertechnetate or perrhenate form in the presence of carbon monoxide. The compound of formula (I) can be reacted with a ligand Lto form a compound of formula (II): fac-[M(CO)(X)L], wherein M is as defined above Lis a multidentate ligand, and n is a charge of the ligand Lincreased with one + charge. The invention also is directed to novel compounds, and kits for carrying out the disclosed methods.