The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 09, 2005
Filed:
Feb. 10, 2003
George E. Wright, Worcester, MA (US);
Wei-chu Xu, Worcester, MA (US);
Neal C. Brown, Greenfield, NH (US);
George E. Wright, Worcester, MA (US);
Wei-Chu Xu, Worcester, MA (US);
Neal C. Brown, Greenfield, NH (US);
GLSynthesis, Inc., Worcester, MA (US);
Abstract
The invention features compounds of the formula:or a pharmaceutically acceptable salt thereof, wherein A is CRand B is N; wherein n is 0-3; wherein Ris (CH)—{(G)—(CH)}—L, in which G is CH, CH═CH, C≡C, CO, O, S, or NR, where Ris H or Calkyl, CHR, where Ris OH or Calkyl, CH(CRR), where each of Rand Ris, independently, H, halo, or Calkyl, OCO, CONR, NRCO, where each of Rand Ris, independently, H or Calkyl, SONH, or NHSO; in which m is 1-4, o is 0-4, p is 0-4, and q is 0-4. The compounds disclosed herein have potent anti-microbial, e.g., both Gram-positive and Gram-negative anti-bacterial properties. The compounds inhibit DNA polymerase IIIC and DNA polymerase IIIE enzymes and thus act therapeutically by inhibiting the growth of a broad array of bacteria. The compounds can be administered to prevent or to treat Gram-positive or Gram-negative bacterial infections, e.g., in eukaryotic cell cultures, animals, or humans.