The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 26, 2005
Filed:
Jun. 11, 2003
Christopher Blackburn, Natick, MA (US);
Su-jen Lai, Somerville, MA (US);
Jennifer L. Che, Cambridge, MA (US);
Martin P. Maguire, Woburn, MA (US);
Michael A. Patane, Andover, MA (US);
Matthew J. Lamarche, Reading, MA (US);
Courtney A. Cullis, Belmont, MA (US);
James Brown, Framingham, MA (US);
Anil Vasudevan, Gurnee, IL (US);
Jennifer C. Freeman, Grayslake, IL (US);
Mathew M. Mulhern, Hainesville, IL (US);
John K. Lynch, Kenosha, WI (US);
Ju Gao, Gurnee, IL (US);
Dariusz Wodka, Waukegan, IL (US);
Andrew J. Souers, Evanston, IL (US);
Rajesh Iyengar, Lindenhurst, IL (US);
Mary Katherin Verzal, Burlington, WI (US);
Philip R. Kym, Grayslake, IL (US);
Christopher Blackburn, Natick, MA (US);
Su-Jen Lai, Somerville, MA (US);
Jennifer L. Che, Cambridge, MA (US);
Martin P. Maguire, Woburn, MA (US);
Michael A. Patane, Andover, MA (US);
Matthew J. LaMarche, Reading, MA (US);
Courtney A. Cullis, Belmont, MA (US);
James Brown, Framingham, MA (US);
Anil Vasudevan, Gurnee, IL (US);
Jennifer C. Freeman, Grayslake, IL (US);
Mathew M. Mulhern, Hainesville, IL (US);
John K. Lynch, Kenosha, WI (US);
Ju Gao, Gurnee, IL (US);
Dariusz Wodka, Waukegan, IL (US);
Andrew J. Souers, Evanston, IL (US);
Rajesh Iyengar, Lindenhurst, IL (US);
Mary Katherin Verzal, Burlington, WI (US);
Philip R. Kym, Grayslake, IL (US);
Abbott Laboratories, Abbott Park, IL (US);
Abstract
This invention provides compounds that are antagonists of melanin concentrating hormone receptor-1 (MCH-R1). The compounds are represented by formula I:where m is zero or one, n is zero to two, Y is oxygen or —N(R)—, R, R, R, R, R, Rand Ring A are defined in the specification. Coumarin and quinolone compounds where Rand Rtogether form a fused benzo ring are preferred. The invention also provides compounds of formula VI where the coumarin moiety is replaced by a quinazolinone ring. The compounds are useful for treating MCH-R1-related disorders, particularly overweight conditions including obesity.