The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 26, 2005
Filed:
Dec. 21, 2001
Roger Briesewitz, Mountain View, CA (US);
Gerald R. Crabtree, Woodside, CA (US);
Thomas Wandless, Menlo Park, CA (US);
Gregory Thomas Ray, Stanford, CA (US);
Kurt William Vogel, Palo Alto, CA (US);
Roger Briesewitz, Mountain View, CA (US);
Gerald R. Crabtree, Woodside, CA (US);
Thomas Wandless, Menlo Park, CA (US);
Gregory Thomas Ray, Stanford, CA (US);
Kurt William Vogel, Palo Alto, CA (US);
The Board of Trustees of the Leland Stanford Junior University, Palo Alto, CA (US);
Howard Hughes Medical Institute, Chevy Chase, MD (US);
Abstract
Bifunctional molecules and methods for their use in the production of binary or tripartite complexes in a host are provided. The bifunctional molecule is a conjugate of a drug moiety and a presenter protein ligand. The molecular weight of the bifunctional molecule is less than about 5000 daltons. In the methods, an effective amount of the bifunctional molecule is administered to the host. In certain embodiments the bifunctional molecule binds to the presenter protein and a drug target to produce a tripartite complex, while in other embodiments the bifunctional molecule binds to either the presenter protein or the drug target, but not both, to produce a binary complex The subject methods and compositions find use in a variety of therapeutic applications.