The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 19, 2005
Filed:
May. 23, 2003
Mark R. Burns, Shoreline, MA (US);
Maralee Mcvean, Seattle, WA (US);
Kevin J. Kennedy, Seattle, WA (US);
Arthur Yeung, Bellevue, WA (US);
Bruce H. Devens, St. Louis, MO (US);
Mark R. Burns, Shoreline, MA (US);
Maralee McVean, Seattle, WA (US);
Kevin J. Kennedy, Seattle, WA (US);
Arthur Yeung, Bellevue, WA (US);
Bruce H. Devens, St. Louis, MO (US);
Mediquest Therapeutics, Inc., Bothell, WA (US);
Abstract
The synthesis and use of a novel class of tumor necrosis factor (TNFα) inhibitors and immunomodulators are provided. These compounds have pharmacological applications as well as uses in assays relating to TNFα and other involved cytokines. As pharmaceuticals, these compounds are used to treat inflammatory, infectious, autoimmune or other proliferative diseases and conditions related to the unwanted presence or activity of TNFα and/or one or more other involved cytokines, alone or in combination with other agents. Examples of compounds of the present invention are those having the structures as shown below: wherein, a, b and c may be the same or different and are integers from 0 to 12, X equals NH or CHNH, Rand Rcan be the same or different and equal to a hydrogen or a straight or branched Cto Csaturated or unsaturated aliphatic; aliphatic amine; an alicyclic; single or multi-ring aromatic; a single or multi-ring aromatic heterocycle; a single or multi-ring saturated heterocycle and the halogenated forms thereof; and