The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 19, 2005
Filed:
Jan. 14, 2003
Noël P. Bouck, Occidental, CA (US);
David W. Dawson, Los Angeles, CA (US);
Paul R. Gillis, San Francisco, CA (US);
Olga Volpert, Wilmette, IL (US);
Susan E. Crawford, Burr Ridge, IL (US);
Veronica M. Stellmach, Chicago, IL (US);
Noël P. Bouck, Occidental, CA (US);
David W. Dawson, Los Angeles, CA (US);
Paul R. Gillis, San Francisco, CA (US);
Olga Volpert, Wilmette, IL (US);
Susan E. Crawford, Burr Ridge, IL (US);
Veronica M. Stellmach, Chicago, IL (US);
Northwestern University, Evanston, IL (US);
Abstract
The present invention provides a method of inhibiting angiogenesis within a tissue by providing exogenous PEDF to cells associated with the tissue. The presence of exogenous PEDF inhibits angiogenesis within the tissue, in part by interfering with the ability of vascular endothelia to expand within the tissue. The invention also provides a method for determining the severity of a tumor by assaying for the presence of PEDF within the tumor. The invention further provides a method of inhibiting endothelial cell migration, a method of stimulating the growth of hair in a mammal, a method for inhibiting the growth of a tumor, a method of inducing differentiation of a neuroblastoma cell, a method of slowing the growth of a neuroblastoma cell, and method of treating ischemic retinopathy in a mammal. To facilitate the inventive methods, the present invention provides pharmaceutical compositions including sources of PEDF.