The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 19, 2005

Filed:

Dec. 10, 2001
Applicants:

Katherine S. Bowdish, Del Mar, CA (US);

Shana Frederickson, Solana Beach, CA (US);

John Mcwhirter, San Diego, CA (US);

Maruyama Toshiaki, San Diego, CA (US);

Inventors:

Katherine S. Bowdish, Del Mar, CA (US);

Shana Frederickson, Solana Beach, CA (US);

John McWhirter, San Diego, CA (US);

Maruyama Toshiaki, San Diego, CA (US);

Assignee:

Alexion Pharmaceuticals, Inc., Cheshire, CT (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12P019/34 ; C12Q001/68 ; C07H021/04 ;
U.S. Cl.
CPC ...
Abstract

Templates that are engineered to contain a predetermined sequence and a hairpin structure are provided by a nested oligonucleotide extension reaction. The engineered template allows Single Primer Amplification (SPA) to amplify a target sequence within the engineered template. In particularly useful embodiments, the target sequences from the engineered templates are cloned into expression vehicles to provide a library of polypeptides or proteins, such as, for example, an antibody library.


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