The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 05, 2005
Filed:
Mar. 24, 2000
Jochen Salfeld, North Grafton, MA (US);
Michael Roguska, Ashland, MA (US);
Michael Paskind, Sterling, MA (US);
Subhashis Banerjee, Shrewsbury, MA (US);
Daniel Tracey, Harvard, MA (US);
Michael White, Framingham, MA (US);
Zehra Kaymakcalan, Westborough, MA (US);
Boris Labkovsky, Marlborough, MA (US);
Paul Sakorafas, Newton, MA (US);
Geertruida M. Veldman, Sudbury, MA (US);
Amy Venturini, Lexington, MA (US);
Angela Widom, Acton, MA (US);
Stuart Friedrich, Melrose, MA (US);
Nicholas W. Warne, Andover, MA (US);
Angela Myles, Andover, MA (US);
John Gawain Elvin, Cambridge, GB;
Alexander Robert Duncan, Little Shelford, GB;
Elaine Joy Derbyshire, Royston, GB;
Sara Carmen, Cambridge, GB;
Thor Las Holtet, Royston, GB;
Sarah Leila Du Fou, Hitchen, GB;
Stephen Smith, Ely, GB;
Jochen Salfeld, North Grafton, MA (US);
Michael Roguska, Ashland, MA (US);
Michael Paskind, Sterling, MA (US);
Subhashis Banerjee, Shrewsbury, MA (US);
Daniel Tracey, Harvard, MA (US);
Michael White, Framingham, MA (US);
Zehra Kaymakcalan, Westborough, MA (US);
Boris Labkovsky, Marlborough, MA (US);
Paul Sakorafas, Newton, MA (US);
Geertruida M. Veldman, Sudbury, MA (US);
Amy Venturini, Lexington, MA (US);
Angela Widom, Acton, MA (US);
Stuart Friedrich, Melrose, MA (US);
Nicholas W. Warne, Andover, MA (US);
Angela Myles, Andover, MA (US);
John Gawain Elvin, Cambridge, GB;
Alexander Robert Duncan, Little Shelford, GB;
Elaine Joy Derbyshire, Royston, GB;
Sara Carmen, Cambridge, GB;
Thor Las Holtet, Royston, GB;
Sarah Leila Du Fou, Hitchen, GB;
Stephen Smith, Ely, GB;
Abbott GmbH & Co. KG, Wiesbaden, DE;
Abstract
Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention.