The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 05, 2005
Filed:
Jun. 24, 2002
Patrick René Angibaud, Fontaine-Bellenger, FR;
Marc Gaston Venet, Le Mesnil-Esnard, FR;
Xavier Marc Bourdrez, Le Vaudreuil, FR;
Patrick René Angibaud, Fontaine-Bellenger, FR;
Marc Gaston Venet, Le Mesnil-Esnard, FR;
Xavier Marc Bourdrez, Le Vaudreuil, FR;
Janssen Pharmaceutica N.V., Beerse, BE;
Abstract
This invention concerns compounds of formulathe pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein ═X—X—X— is a trivalent radical,; >Y—Y— is a trivalent radical; r and s are each independently 0, 1, 2, 3, 4 or 5; t is 0, 1, 2 or 3; each Rand Rare independently hydroxy, halo, cyano, Calkyl, trihalomethyl, trihalomethoxy, Calkenyl, Calkyloxy, hydroxyCalkyloxy, Calkylthio, CalkyloxyCalkyloxy, Calkyloxycarbonyl, aminoCalkyloxy, mono- or di(Calkyl)amino, mono- or di(CalkylaminoCalkyloxy, aryl, arylCalkyl, aryloxy or arylCalkyloxy, hydroxycarbonyl, Calkyloxycarbonyl; or two Ror Ron adjacent positions form together a bivalent radical; Ris hydrogen, halo, Calkyl, cyano, haloCalkyl, hydroxyCalkyl, cyanoCalkyl, aminoCalkyl, CalkyloxyCalkyl, Calkylthio-Calkyl, aminocarbonylCalkyl, hydroxycarbonyl, hydroxycarbonylCalkyl, CalkyoxycarbonylCalkyl, CalkylcarbonylCalkyl, Calkyloxycarbonyl, aryl, arylCalkyloxyCalkyl, mono- or di(Calkyl)aminoCalkyl, or a radical of formula —O—R, —S—Ror —NRR; Ris an optionally substituted imidazolyl; aryl is an optionally substituted phenyl or naphthalenyl; having farnesyl transferase and geranylgeranyl transferase inhibiting activity; their preparation, compositions containing them and their use as a medicine.