The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 05, 2005
Filed:
Mar. 13, 2002
Larry W. Mclaughlin, Dover, MA (US);
Andrew W. Fraley, WestNewton, MA (US);
Dongli Chen, Chestnut Hill, MA (US);
Tao Lan, Somerville, MA (US);
Larry W. McLaughlin, Dover, MA (US);
Andrew W. Fraley, WestNewton, MA (US);
DongLi Chen, Chestnut Hill, MA (US);
Tao Lan, Somerville, MA (US);
The Trustees of Boston College, Chestnut Hill, MA (US);
Abstract
The present invention relates to dideoxynucleoside analog compounds containing a dideoxy ribofuranosyl moiety that exhibit selective anti-viral activity coupled with substantially low toxicity toward the host cells. In particular, the compounds according to the present invention show potent inhibition of the replication of the human immunodeficiency virus (HIV), while remaining substantially inert toward host cell DNA. Compounds according to the present invention exhibit primary utility as agents for inhibiting the growth or replication of retroviruses, particularly HIV. The compounds of the invention comprise a (2,3'-dideoxy-β-ribofuranosyl) ring coupled to a heterocyclic nucleobase that lacks an 'O2 carbonyl', that enables them to selectively react with and inhibit viral reverse transcriptase, while remaining substantially unreactive toward human DNA polymerases.