The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 28, 2005
Filed:
Dec. 04, 2002
Armin Hofmeister, Oppenheim, DE;
Uwe Heinelt, Wiesbaden, DE;
Hans-jochen Lang, Hofheim, DE;
Markus Bleich, Hünfelden-Dauborn, DE;
Klaus Wirth, Kriftel, DE;
Michael Gekle, Würzburg, DE;
Armin Hofmeister, Oppenheim, DE;
Uwe Heinelt, Wiesbaden, DE;
Hans-Jochen Lang, Hofheim, DE;
Markus Bleich, Hünfelden-Dauborn, DE;
Klaus Wirth, Kriftel, DE;
Michael Gekle, Würzburg, DE;
Aventis Pharma Deutschland GmbH, Frankfurt, DE;
Abstract
The invention relates to compounds of the formula Iin which R1 to R9 are as defined herein. In one embodiment, these compounds may be used as antihypertensives, for reducing or preventing ischemia-induced damage, as medicaments for surgical intervention for the treatment of ischemias of the nervous system, of stroke and of cerebral edema, of shock, of impaired respiratory drive, for the treatment of snoring, as laxative, as agent against ectoparasites, to prevent the formation of gallstones, as antiatherosclerotics, agents against late complications of diabetes, cancers, fibrotic disorders, endothelial dysfunction, organ hypertrophies and hyperplasias. In one embodiment, the compounds may be inhibitors of the cellular sodium-proton antiporter and influence serum lipoproteins and thus be used for the prophylaxis and for the regression of atherosclerotic lesions.