The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 28, 2005
Filed:
Nov. 21, 2002
John C. Reed, Rancho Santa Fe, CA (US);
Richard A. Houghten, Solana Beach, CA (US);
Adel Nefzi, San Diego, CA (US);
John M. Ostresh, Encinitas, CA (US);
Clemencia Pinilla, Cardiff, CA (US);
Kate Welsh, San Diego, CA (US);
John C. Reed, Rancho Santa Fe, CA (US);
Richard A. Houghten, Solana Beach, CA (US);
Adel Nefzi, San Diego, CA (US);
John M. Ostresh, Encinitas, CA (US);
Clemencia Pinilla, Cardiff, CA (US);
Kate Welsh, San Diego, CA (US);
The Burnham Institute, La Jolla, CA (US);
Torrey Pines Institute for Molecular Studies, San Diego, CA (US);
Abstract
The invention provides isolated agents having a core peptide selected from the group consisting of Core peptides 5 through 39 and 42 through 55, wherein the agent derepresses an IAP-inhibited caspase. Also provided is an isolated agent having a core structure selected from any of the structures shown in FIGS.B, andwherein said agent derepresses an IAP-inhibited caspase. The invention further provides a method of derepressing an IAP-inhibited caspase. The method consists of contacting an IAP-inhibited caspase with an effective amount of an agent to derepress an IAP-inhibited caspase, the agent having a core motif selected from the group consisting of a core peptide having a sequence set forth in any of Core peptides 4 through 39 and 42 through 55, and a core structure selected from the group consisting of TPI759, TPI882, TPI914 or TPI927. The methods of the invention also can be used for promoting apoptosis in a cell and for reducing the severity of a pathology characterized by reduced levels of apoptosis. Methods for identifying agents that derepress an IAP-inhibited caspase are also provided.