The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 21, 2005

Filed:

Oct. 25, 2001
Applicants:

Joachim Brendel, Bad Vilbel, DE;

Hans Jochen Lang, Hofheim, DE;

Uwe Gerlach, Hattersheim, DE;

Inventors:

Joachim Brendel, Bad Vilbel, DE;

Hans Jochen Lang, Hofheim, DE;

Uwe Gerlach, Hattersheim, DE;

Assignee:

Aventis Pharma Deutschland GmbH, Frankfurt Am Main, DE;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61P009/00 ; A61K031/16 ; A61K031/18 ; C07C381/00 ; C07C303/00 ;
U.S. Cl.
CPC ...
Abstract

The present invention relates to compounds of formula I,in which X1, X2, X3, X4, Y1, Y2, Y3, Y4, R(3), R(4) and R(5) have the meanings mentioned in the specification, their preparation and their use, in particular in pharmaceuticals. The compounds effect the potassium channel or the Ichannel opened by cyclic adenosine monophosphate (cAMP) and are outstandingly suitable as pharmaceutical active compounds, for example for the prophylaxis and therapy of cardiovascular disorders, in particular arrhythmias, for the treatment of ulcers of the gastrointestinal region or for the treatment of diarrheal disorders.


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