The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 21, 2005
Filed:
Nov. 10, 1998
Richard T. Wyatt, Andover, MA (US);
Joseph G. Sodroski, Medford, MA (US);
Peter D. Kwong, New York, NY (US);
Wayne A. Hendrickson, Hastings on Hudson, NY (US);
Richard T. Wyatt, Andover, MA (US);
Joseph G. Sodroski, Medford, MA (US);
Peter D. Kwong, New York, NY (US);
Wayne A. Hendrickson, Hastings on Hudson, NY (US);
Dana-Farber Cancer Institute, Inc., Boston, MA (US);
The Trustees of Columbia University in the City of New York, New York, NY (US);
Abstract
A modified polypeptide corresponding to an envelope glycoprotein of a primate lentivirus is described. The polypeptide has been modified from the wild-type structure so that it has at least two of the glycosylation sites proximal to the CD4 binding site or chemokine receptor site altered so that the alteration prevents glycosylation at that site or where glycosylation sites distal to these sites have been derivatized with a molecular adjuvant, while retaining the overall 3-dimensional structure of a discontinuous conserved epitope of the wild-type protein. Preferably, the polypeptide has both changes. Preferably, the primate lentivirus is HIV, and the protein is HIV-1 gp 120.