The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 14, 2005
Filed:
Jan. 29, 2003
James David White, Philomath, OR (US);
Kurt Frederick Sundermann, Burlingame, CA (US);
Rich Garrett Carter, Corvallis, OR (US);
James David White, Philomath, OR (US);
Kurt Frederick Sundermann, Burlingame, CA (US);
Rich Garrett Carter, Corvallis, OR (US);
Abstract
A method for making epothilones and epothilone analogs is described, as are novel compounds made by the method. Exemplary novel compounds include those according to the formula:With respect the formula, G is selected from the group consisting ofRsubstituents independently are selected from the group consisting of H and lower alkyl groups; Z is selected from the group consisting of the halogens and —CN; M is selected from the group consisting of O and NR; Ris selected from the group consisting of H, lower alkyl, RCO, ROCO, and RSO; Ris selected from the group consisting of H, lower alkyl, and aryl; T is selected from the group consisting of CH, CO, HCOH and protected derivatives thereof; W is H or OR; and X and Y independently are selected from the group consisting of O, NH, S, CO, and C. Embodiments of the method provide convenient access to analogs of the epothilones, such as those having alternate stereochemistry and those containing an ester, amide, thioester, or alkyne moieties in the macrocycle.