The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 14, 2005
Filed:
Jan. 18, 2001
Noboru Yamamoto, Ibaraki, JP;
Yuichi Suzuki, Ibaraki, JP;
Manami Kimura, Chiba, JP;
Tetsuhiro Niidome, Ibaraki, JP;
Yoichi Iimura, Ibaraki, JP;
Tetsuyuki Teramoto, Brookline, MA (US);
Yoshihisa Kaneda, Ibaraki, JP;
Toshihiko Kaneko, Ibaraki, JP;
Nobuyuki Kurusu, Ibaraki, JP;
Daisuke Shinmyo, Ibaraki, JP;
Yukie Yoshikawa, Ibaraki, JP;
Shinji Hatakeyama, Ibaraki, JP;
Noboru Yamamoto, Ibaraki, JP;
Yuichi Suzuki, Ibaraki, JP;
Manami Kimura, Chiba, JP;
Tetsuhiro Niidome, Ibaraki, JP;
Yoichi Iimura, Ibaraki, JP;
Tetsuyuki Teramoto, Brookline, MA (US);
Yoshihisa Kaneda, Ibaraki, JP;
Toshihiko Kaneko, Ibaraki, JP;
Nobuyuki Kurusu, Ibaraki, JP;
Daisuke Shinmyo, Ibaraki, JP;
Yukie Yoshikawa, Ibaraki, JP;
Shinji Hatakeyama, Ibaraki, JP;
Eisai Co., Ltd., Tokyo, JP;
Abstract
The present invention provides a novel compound having a superior calcium antagonism, in particular, a neuron-selective calcium antagonism. Namely, it provides a compound represented by the following formula, a salt thereof or a hydrate of them.In the formula, Ar indicates an optionally substituted 5- to 14-membered aromatic ring etc.; the ring A indicates any one ring selected from a piperazine, a homopiperazine, a piperidine and the like; the ring B indicates an optionally substituted Con hydrocarbon ring etc.; E indicates a single bond, a group represented by the formula —CO—, etc.; X indicates a single bond, an oxygen atom etc.; Rindicates a hydrogen atom, a halogen atom, a hydroxyl group etc.; and D, D, Wand Ware the same as or different from each other and each represents a single bond or an optionally substituted Calkylene chain.