The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 14, 2005
Filed:
Jun. 29, 2000
Antónia Jekkel, Budapest, HU;
Gábor Ambrus, Budapest, HU;
Éva Ilkóy, Budapest, HU;
Ildikó Horváth, Budapest, HU;
Attila Kónya, Dunakeszi, HU;
István Mihály Szabó, Budapest, HU;
Zsuzsanna Nagy, Budapest, HU;
Gyula Horváth, Budapest, HU;
Júlia Mózes, Ecser, HU;
István Barta, Budapest, HU;
György Somogyi, Budapest, HU;
János Salát, Budapest, HU;
Sándor Boros, Szöd, HU;
Antónia Jekkel, Budapest, HU;
Gábor Ambrus, Budapest, HU;
Éva Ilkóy, Budapest, HU;
Ildikó Horváth, Budapest, HU;
Attila Kónya, Dunakeszi, HU;
István Mihály Szabó, Budapest, HU;
Zsuzsanna Nagy, Budapest, HU;
Gyula Horváth, Budapest, HU;
Júlia Mózes, Ecser, HU;
István Barta, Budapest, HU;
György Somogyi, Budapest, HU;
János Salát, Budapest, HU;
Sándor Boros, Szöd, HU;
IVAX Drug Research Institute, Budapest, HU;
Abstract
The present invention relates to a new microbial process for the preparation of compound of formula (I) from a compound of general formula (II) wherein R stands for an alkali metal or ammonium ion, by the submerged culture of a strain which is able to 6β-hydroxylate the compound of formula (II) in aerobic fermentation and by the separation and purification of the product of formula (I) formed in the course of the bioconversion. The latter comprises the cultivation of astrain which is able to 6β-hydroxylate a compound of general formula (II)—wherein R is as defined above—at 25-32° C. on a nutrient medium containing available carbon—and nitrogen sources and mineral salts, thereafter feeding the substrate to be transformed into the developing culture, then hydroxilating the substrate until finishing of the bioconversion, then separating the compound of formula (I) from the culture broth and, if desired, purifying the same.