The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 14, 2005
Filed:
Apr. 14, 2003
Applicants:
David M. Roof, San Carlos, CA (US);
Mary Maxon, San Francisco, CA (US);
Inventors:
David M. Roof, San Carlos, CA (US);
Mary Maxon, San Francisco, CA (US);
Assignee:
Cytokinetics, Inc., South San Francisco, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q001/16 ; C12Q001/68 ; C12Q001/48 ; C12Q001/02 ;
U.S. Cl.
CPC ...
Abstract
Provided are methods of identifying potential antifungal agents, and particularly those having antimitotic activity. Fungal cells having double mutations which alter microtubule stability and inhibit cell proliferation are used in the methods. Test compounds are screened to identify those which are able to promote cell proliferation o the mutant fungal cells and counteract the stabilizing effect of the double mutations on the microtubules. High-throughput methods of selecting for the novel antifungal agents are also provided.