The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 14, 2005
Filed:
May. 30, 2000
Erich Wanker, Berlin, DE;
David Bancroft, Gilching, DE;
Hans Lehrach, Berlin, DE;
Niels Wedemeyer, Norwalde, DE;
Elmar Maier, Schäftlam, DE;
Sebastian Meier-ewert, Gelting, DE;
Erich Wanker, Berlin, DE;
David Bancroft, Gilching, DE;
Hans Lehrach, Berlin, DE;
Niels Wedemeyer, Norwalde, DE;
Elmar Maier, Schäftlam, DE;
Sebastian Meier-Ewert, Gelting, DE;
Abstract
The present invention relates to an improved method for the identification and optionally the characterisation of interacting molecules designed to detect positive clones from the rather large numbers of false positive clones isolated by conventional two-hybrid systems. The method of the invention relies on a novel combination of selection steps used to detect clones that express interacting molecules from false positive clones. The present invention provides for high-throughput interaction screens for the reliable identification of interacting molecules, which in turn can lead to the identification of substances inhibiting said interactions. Such inhibitors can find their use in the formulation of a pharmaceutical composition. The present invention further relates to kits useful for carrying out the method of the invention.