The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 07, 2005
Filed:
Nov. 10, 2000
John C. Royer, Davis, CA (US);
Lynne M. Christianson, Davis, CA (US);
Gregory A. Gambetta, San Carlos, CA (US);
Howard Brody, Davis, CA (US);
Suzanne M. Otani, ELk Grove, CA (US);
Wendy T. Yoder, Winters, CA (US);
John C. Royer, Davis, CA (US);
Lynne M. Christianson, Davis, CA (US);
Gregory A. Gambetta, San Carlos, CA (US);
Howard Brody, Davis, CA (US);
Suzanne M. Otani, ELk Grove, CA (US);
Wendy T. Yoder, Winters, CA (US);
Novozymes Biotech, Inc., Davis, CA (US);
Abstract
The present invention relates to methods for producing a polypeptide, comprising: (a) cultivating a mutant of a parent filamentous fungal cell under conditions conducive for the production of the polypeptide, wherein (i) the mutant cell comprises a first nucleic acid sequence encoding the polypeptide and a second nucleic acid sequence comprising a modification of at least one of the genes involved in the production of a trichothecene and (ii) the mutant produces less trichothecene than the parent filamentous fungal cell when cultured under the same conditions; and (b) isolating the polypeptide from the cultivation medium. The present invention also relates to mutants of filamentous fungal cells and methods for obtaining the mutant cells, isolated trichodiene synthases and nucleic acid sequences encoding the trichodiene synthases.