The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 07, 2005
Filed:
Nov. 09, 2001
Johannes-peter Stasch, Solingen, DE;
Achim Feurer, Wilhelmsfeld, DE;
Stefan Weigand, Wuppertal, DE;
Elke Stahl, Bergisch Gladbach, DE;
Dietmar Flubacher, Freiburg, DE;
Cristina Alonso-alija, Haan, DE;
Frank Wunder, Wuppertal, DE;
Dieter Lang, Velbert, DE;
Klaus Dembowsky, Boston, MA (US);
Alexander Straub, Wuppertal, DE;
Elisabeth Perzborn, Wuppertal, DE;
Johannes-Peter Stasch, Solingen, DE;
Achim Feurer, Wilhelmsfeld, DE;
Stefan Weigand, Wuppertal, DE;
Elke Stahl, Bergisch Gladbach, DE;
Dietmar Flubacher, Freiburg, DE;
Cristina Alonso-Alija, Haan, DE;
Frank Wunder, Wuppertal, DE;
Dieter Lang, Velbert, DE;
Klaus Dembowsky, Boston, MA (US);
Alexander Straub, Wuppertal, DE;
Elisabeth Perzborn, Wuppertal, DE;
Bayer Aktiengesellschaft, Leverkusen, DE;
Abstract
The invention relates to novel pyrazolopyridine derivatives of formula (I)wherein Rrepresents NHor NHCO-C-alkyl, and Rrepresents a radical of formula RNCORwhich is bonded to the remainder of the molecule by means of the nitrogen atom, Rand Rforming, together with the amide group to which they are bonded, a five to seven-membered heterocycle which may be saturated or partially unsaturated, may optionally contain a further heteroatom selected from the group N, O, and S and may comprise between one and five other substituents chosen from oxo, Calkyl, hydroxyl, hydroxy-C-alkyl, halogen, or may be fused to a CARYL ring or a Ccycloalkyl ring in which optionally two carbon atoms are bonded to each other by means of an oxygen atom. The invention also relates to salts, isomers and hydrates of the derivatives in the form of stimulators of soluble guanylate cyclase and as agents for treating cardiovascular diseases, hypertonia, thrombo-embolic diseases and ischaemia, sexual dysfunction, inflammations, and diseases of the central nervous system. Processes for preparing these materials, and pharmaceutical compositions containing them are also disclosed and claimed.