The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 07, 2005
Filed:
Nov. 16, 2001
Gregory H. Altman, Dedham, MA (US);
David L. Kaplan, Concord, MA (US);
Rebecca L. Horan, Westfield, MA (US);
David J. Horan, Westfield, MA (US);
Gregory H. Altman, Dedham, MA (US);
David L. Kaplan, Concord, MA (US);
Rebecca L. Horan, Westfield, MA (US);
David J. Horan, Westfield, MA (US);
Tissue Regeneration, Inc., Medford, MA (US);
Trustees of Tufts College, Medford, MA (US);
Abstract
The present invention provides a novel silk-fiber-based matrix having a wire-rope geometry for use in producing a ligament or tendon, particularly an anterior cruciate ligament, ex vivo for implantation into a recipient in need thereof. The invention further provides the novel silk-fiber-based matrix which is seeded with pluripotent cells that proliferate and differentiate on the matrix to form a ligament or tendon ex vivo. Also disclosed is a bioengineered ligament comprising the silk-fiber-based matrix seeded with pluripotent cells that proliferate and differentiate on the matrix to form the ligament or tendon. A method for producing a ligament or tendon ex vivo comprising the novel silk-fiber-based matrix is also disclosed.