The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 31, 2005
Filed:
Dec. 28, 2000
Nicholas C. Nicolaides, Boothwyn, PA (US);
Luigi Grasso, Philadelphia, PA (US);
Phillip M. Sass, Audubon, PA (US);
Ken Kinzler, Bel Air, MD (US);
Bert Vogelstein, Baltimore, MD (US);
Nicholas C. Nicolaides, Boothwyn, PA (US);
Luigi Grasso, Philadelphia, PA (US);
Phillip M. Sass, Audubon, PA (US);
Ken Kinzler, Bel Air, MD (US);
Bert Vogelstein, Baltimore, MD (US);
John Hopkins University, Baltimore, MD (US);
Morphotek, Inc., Philadelphia, PA (US);
Abstract
Blockade of mismatch repair in a plant can lead to hypermutation and a new genotype and/or phenotype. One approach used to generate hypermutable plants is through the expression of dominant negative alleles of mismatch repair genes in transgenic plants or derived cells. By introducing these genes into cells and transgenic plants, new cell lines and plant varieties with novel and useful properties can be prepared more efficiently than by relying on the natural rate of mutation. Moreover, methods to inhibit the expression and activity of endogenous plant MMR genes and their encoded products are also useful to generate hypermutable plants.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile