The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 31, 2005
Filed:
Feb. 05, 2002
Karen S. Anderson, Guilford, CT (US);
Adrian Staffin Ray, New Haven, CT (US);
Chung K. Chu, Athens, GA (US);
Yang Zhenjun, Athens, GA (US);
Karen S. Anderson, Guilford, CT (US);
Adrian Staffin Ray, New Haven, CT (US);
Chung K. Chu, Athens, GA (US);
Yang Zhenjun, Athens, GA (US);
Yale University, Athens, CT (US);
University of Georgia Research Foundation, Inc., Athens, GA (US);
Abstract
The present invention relates to novel compounds, compositions and methods for inhibiting the growth, elaboration and/or replication of HIV in human patients and to the prevention and treatment of human acquired immunodeficiency syndrome (AIDS) and other diseases caused by retroviral infection. More particularly, in preferred aspects, the present invention provides a method for the use of novel prodrug forms of 9-(2,3-Dideoxy-β-D-glycero-pent-2-enofuranosyl) guanine (d4G) for the prevention and treatment of both wild type and drug-resistant Human Immunodeficiency Virus (HIV), the causative pathogen of AIDS. Compounds according to the present invention are based upon the chemical formula:where X is OCH, N, NHCH, N(CH)or an aminocyclopropyl group;