The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 31, 2005
Filed:
Sep. 26, 2003
Ivan Alferiev, Clementon, NJ (US);
Ilia Fishbein, Philadelphia, PA (US);
Robert J. Levy, Merion Station, PA (US);
Ivan Alferiev, Clementon, NJ (US);
Ilia Fishbein, Philadelphia, PA (US);
Robert J. Levy, Merion Station, PA (US);
The Children's Hospital of Philadelphia, Philadelphia, PA (US);
Abstract
A process for preparing the polyurethane derivative, the process including: providing a polyurethane having a urethane amino moiety, providing a multifunctional linker reagent of a formula: LG-R-(FG), wherein n is an integer from 1 to 3, FG is a functional group, which is a halogen, a carboxyl group, a sulfonate ester, or an epoxy group, LG is a leaving group, which is a halogen, a carboxyl group, a sulfonate ester, or an epoxy group, and Ris an (n+1)-valent organic radical having at least one carbon atom; providing a protected thiol-containing reagent of a formula R—C(O)SH, or a salt thereof, wherein R is a Cto Calkyl group; reacting the multifunctional linker reagent with the urethane amino moiety to form a polyurethane substituted with at least one substituent group of a formula: —R-(FG); reacting the polyurethane with a protected thiol-containing reagent to form the polyurethane derivative.