The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 31, 2005

Filed:

Apr. 10, 2002
Applicants:

Amedeo Arturo Failli, Princeton Junction, NJ (US);

Jay Scott Shumsky, Hightstown, NJ (US);

Thomas Joseph Caggiano, Morrisville, PA (US);

Joseph P. Sabatucci, Collegeville, PA (US);

Eugene John Trybulski, Princeton Junction, NJ (US);

Kevin Anthony Memoli, Cranbury, NJ (US);

William Jennings Sanders, Fox Lake, IL (US);

Inventors:

Amedeo Arturo Failli, Princeton Junction, NJ (US);

Jay Scott Shumsky, Hightstown, NJ (US);

Thomas Joseph Caggiano, Morrisville, PA (US);

Joseph P. Sabatucci, Collegeville, PA (US);

Eugene John Trybulski, Princeton Junction, NJ (US);

Kevin Anthony Memoli, Cranbury, NJ (US);

William Jennings Sanders, Fox Lake, IL (US);

Assignee:

Wyeth, Madison, NJ (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D487/04 ; A61K031/5517 ; A61P015/16 ;
U.S. Cl.
CPC ...
Abstract

This invention provides novel substituted tricyclic carboxamides which act as oxytocin receptor competitive antagonists, as well as methods of their manufacture, pharmaceutical compositions and methods of their use in treatment, inhibition, suppression or prevention of preterm labor, dysmenorrhea and endometritis, suppression of labor at term prior to caesarean delivery, and to facilitate antinatal transport to a medical facility. These compounds are also useful in enhancing fertility rates, enhancing survival rates and synchronizing estrus in farm animals; and may be useful in the prevention and treatment of disfunctions of the oxytocin system in the central nervous system including obsessive compulsive disorder (OCD) and neuropsychiatric disorders.


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