The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 31, 2005
Filed:
Dec. 27, 2002
Kai-uwe Lewandrowski, Brookline, MA (US);
Shrikar Bondre, Malden, MA (US);
Debra J. Trantolo, Princeton, MA (US);
Maurice V. Cattaneo, Quincy, MA (US);
Joseph D. Gresser, Brookline, MA (US);
Donald L. Wise, Belmont, MA (US);
Kai-Uwe Lewandrowski, Brookline, MA (US);
Shrikar Bondre, Malden, MA (US);
Debra J. Trantolo, Princeton, MA (US);
Maurice V. Cattaneo, Quincy, MA (US);
Joseph D. Gresser, Brookline, MA (US);
Donald L. Wise, Belmont, MA (US);
Cambridge Scientific, Inc., Boston, MA (US);
Abstract
A method by which immune responses to cortical bone grafts and other substrates (e.g., cement, IPN, etc.) can be minimized and at the same time graft osteoinductive potential can be improved, and improved graft substrate materials are disclosed. The method of the invention provides new types of bone grafts that incorporate into host bone more thoroughly and more rapidly, eliminating long-term complications, such as fracture, non-union, infection, and rejection. In the method of the invention, bone grafts or other substrates are modified to have an osteoinductive surface modification that the recipient's body will accept as its own tissue type and therefore will not reject or otherwise cause to fail. The osteoinductive surface modification comprises a biopolymer matrix coating that is seeded with periosteal cells that have been previously harvested either from the graft recipient or from an allogenic or xenogenic donor source.