The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 24, 2005
Filed:
Aug. 07, 2003
Jeffrey Depue, Hillsborough, NJ (US);
Atul S. Kotnis, Kendall Park, NJ (US);
Simon Leung, Piscataway, NJ (US);
Eric D. Dowdy, San Mateo, CA (US);
Daniel J. Watson, Princeton, NJ (US);
Jeffrey Depue, Hillsborough, NJ (US);
Atul S. Kotnis, Kendall Park, NJ (US);
Simon Leung, Piscataway, NJ (US);
Eric D. Dowdy, San Mateo, CA (US);
Daniel J. Watson, Princeton, NJ (US);
Bristol-Myers Squibb Company, Princeton, NJ (US);
Abstract
This invention describes a process for preparing hydroxyazapirones of Formula I from azapirones of Formula II. The process comprises treating azapirones with a strong base, monitoring enolate formation of the azapirone by IR spectroscopy, and reacting the enolate with a source of molecular oxygen in the presence of a reductant. The process is suitable for large scale production of hydroxyazapirones.