Aminobenzophenones as inhibitors of il-1β and tnf-α

Abstract

The present invention relates to compounds of formula (I) wherein R, Rand Rindependently represent one or more, same or different substituents selected from the group consisting of hydrogen, halogen, hydroxy, mercapto, trifluoromethyl, amino, (C-C)alkyl, (C-C)olefinic group, (C-C)alkoxy, (C-C)alkylthio, (C-C)alkylamino, (C-C)alkoxycarbonyl, cyano, carbamoyl, or phenyl; Rand Rfurther represented by nitro and Rby carboxy; Rrepresents hydrogen, (C-C)alkyl, or allyl; Q represents a bond, or —C(R)(R)(—O—C═O)—, in which formula Rand Rindependently represent hydrogen, trifluoromethyl, or (C-C)alkyl; Y represents either (C-C)alkyl, (C-C)olefinic group, (C-C)monocyclic hydrocarbon, or phenyl, any of which may be optionally substituted with one or more, same or different substituents represented by the formula R; or (C-C)alkyl substituted with at least one or more substituents with the formula R; or Y represents a group of formula —CH—(Z—O)—Z where Z is a (C-C)alkyl, where n is a integer>1 and no continuous linear sequence of atoms in the group Y>15; Rrepresents halogen, hydroxy, mercapto, trifluoromethyl, amino, (C-C)alkoxy, (C-C)alkylthio, (C-C)alkylamino, (C-C)alkoxycarbonyl, cyano, azido, nitro, —COOH, —CONH, —CONHR', or —COONR′R′ wherein R′ stands for (C-C)alkyl; X represents oxygen or sulphur, or a pharmaceutically acceptable salt thereof, or a hydrate or solvate thereof. The compounds are valuable in the human and veterinary therapy.