Method for the preparation of enantiomerically enriched amines

Abstract

Method for the preparation of an enantiomerically enriched acylated amine wherein a phenylacetic acid derivative is brought into contact with a mixture of enantiomers of an amine HNCRRR, in which R, R, Rare not equal to each other and each independently stand for H, CN, a whether or not substituted (cyclo)alkyl, ary-, alkylaryl or arylalkyl group, whether or not cyclic heteroalkyl or heteroaryl group with one or more N, O or S atoms or in which Rand R(and R) together with the C-atom to which they have been bound form a (bi)cyclic group that optionally contains one or more N, O of S atoms, in the presence of a Pen-G acylase derived from And method for the preparation of enantiomerically enriched amine of formula HNCRRR, in which R, R, Rare as defined above, wherein an acylated amine is brought into contact with a Pen-G acylase originating from. Preferably enantiomerically enriched phenylglycine amide or an ester of p-hydroxyphenylglycine is applied as phenylacetic acid derivative.