The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 17, 2005
Filed:
Oct. 15, 2002
Sylvia Krich, Altenberg b. Linz, AT;
Alexander Rieder, Kundl, AT;
Ferdinand Heu, Linz, AT;
Gerhard Steinbauer, Enns, AT;
Sylvia Krich, Altenberg b. Linz, AT;
Alexander Rieder, Kundl, AT;
Ferdinand Heu, Linz, AT;
Gerhard Steinbauer, Enns, AT;
DSM Fine Chemicals Austria Nfg GmbH & Co KG, Linz, AT;
Abstract
Process for the preparation of substituted thiazolines of the formula (I)in which Ar is a phenyl, naphthyl, thienyl, pyridyl or quinolinyl radical which can optionally be substituted by one or more substituents from the group consisting of halogen, OH, benzyloxy, C-C-alkyl, C-C-alkoxy, COORwhere Ris H or C-C-alkyl,by coupling of (S)-α-methylcysteine hydrochloride of the formula (II)with a nitrile of the formula (III)Ar—CNin which Ar is as defined above, or a corresponding C-C-alkyl imidate, in which (S)-α-methylcysteine hydrochloride of the formula (II) is reacted in a suitable solvent with a nitrile of the formula (III) or a corresponding C-C-alkyl imidate in the presence of a tertiary base at a pH of 6.5 to 10 at 50° C. up to the reflux temperature to give the corresponding thiazoline of the formula (I), and processes for the preparation of (S)-α-methylcysteine hydrochloride and its use for the preparation of thiazolines of the formula (I).