The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 17, 2005
Filed:
Mar. 23, 2000
Ralph Scannell, Hopkinson, MA (US);
Pierre Chatelain, Woluwe Saint Pierre, BE;
Anna Toy-palmer, Arlington, MA (US);
Edmund Differding, Louvain-La-Neuve, BE;
James Ellis, Boxford, MA (US);
Marie-agnes Lassoie, Braine-Le-Chateau, BE;
Michelle Young, Belmont, MA (US);
Xiong Cai, Belmont, MA (US);
Sajjat Hussoin, Lexington, MA (US);
Gurmit Grewal, Natick, MA (US);
Timothy Lewis, Framingham, MA (US);
Ralph Scannell, Hopkinson, MA (US);
Pierre Chatelain, Woluwe Saint Pierre, BE;
Anna Toy-Palmer, Arlington, MA (US);
Edmund Differding, Louvain-La-Neuve, BE;
James Ellis, Boxford, MA (US);
Marie-Agnes Lassoie, Braine-Le-Chateau, BE;
Michelle Young, Belmont, MA (US);
Xiong Cai, Belmont, MA (US);
Sajjat Hussoin, Lexington, MA (US);
Gurmit Grewal, Natick, MA (US);
Timothy Lewis, Framingham, MA (US);
UCB S.A., Brussels, BE;
Abstract
The present invention provides 1,4 substituted piperazines, 1,4 substituted piperidines, and 1-substituted, 4-alkylidenyl piperidines compounds. The compounds of the invention are dual acting molecules having both leukotriene inhibition properties as well as antihistaminergic properties. The compounds of the invention are useful for treating conditions in which there is likely to be a histamine and/or leukotriene component. These conditions include preferably asthma, seasonal and perennial allergic rhinitis, sinusitus, conjunctivitis, food allergy, scombroid poisoning, psoriasis, urticaria, pruritus, eczema, rheumatoid arthritis, inflammatory bowel disease, chronic obsructive pulmonary disease, thrombotic disease and otitis media. Also provided are methods of treating asthma and rhinitis by administering an effective asthma and rhinitis-relieving amount of the compounds to a subject in need thereof.