Il-5 inhibiting 6-azauracil derivatives

Abstract

The present invention is concerned with the compounds of formulathe N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein p is 0 to 4; X is O, S, NRor a direct bond; Y is O, S, NRor S(O); Rindependently is Calkyl, halo, polyhaloCalkyl, hydroxy, mercapto, Calkyloxy, Calkylthio, Calkylcarbonyloxy, aryl, cyano, nitro, Het, R, NRRor substituted Calkyl; Ris Het, Ccycloalkyl or optionally substituted Calkyl and if X is O, S or NR, then Rmay also represent aminocarbonyl, aminothiocarbonyl, Calkylcarbonyl, Calkylthiocarbonyl, arylcarbonyl, arylthiocarbonyl, Hetcarbonyl or Hetthiocarbonyl; Rand Rindependently are hydrogen, Calkyl or Ccycloalkyl; Rand Rform a Calkanediyl; Ris hydrogen or Calkyl; Ris a sulfonyl or sulfinyl derivative; Rand Rare independently hydrogen, optionally substituted Calkyl, aryl, a carbonyl containing moiety, Ccycloalkyl, —Y—Calkanediyl-C(═O)—O—R, Het, Hetand R; Ris hydroxy, mercapto, cyano, nitro, halo, trihalomethyl, Calkyloxy, formyl, trihaloCalkylsulfonyloxy, R, NRR, C(═O)NRR, Calkanediyl-C(═O)—O—R, —C(═O)—O—R, —Y—Calkanediyl-C(═O)—O—R, aryl, aryloxy, arylcarbonyl, Ccycloalkyl, Ccycloalkyloxy, phthalimide--yl, Hetand C(═O)Het; Ris hydrogen, Calkyl, Ccycloalkyl, aminocarbonylmethylene or mono- or di(Calkyl)aminocarbonylmethylene; aryl is optionally substituted phenyl; Het, Het, Hetand Hetare optionally substituted heterocycles; to processes for their preparation and compositions comprising them. It further relates to their use as a medicine.