The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 10, 2005
Filed:
Sep. 16, 2003
Applicants:
Pranhitha Reddy, Seattle, WA (US);
Brian D. Rasmussen, Bellevue, WA (US);
Inventors:
Pranhitha Reddy, Seattle, WA (US);
Brian D. Rasmussen, Bellevue, WA (US);
Assignee:
Immunex Corporation, Thousand Oaks, CA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12P021/06 ;
U.S. Cl.
CPC ...
Abstract
The invention provides a method for increasing production of a protein by cultured mammalian cells comprising adding a DNA demethylating agent, for example a cytidine analogue, to the mammalian cell culture. The cytidine analogue can be 5-aza-2'-deoxycytidine (also called decitabine) or 5-bromo-2′-deoxycytidine-5′-monophosphate, among many other possible cytidine analogues.