The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 03, 2005
Filed:
Nov. 20, 2001
Adenine based inhibitors of adenylyl cyclase, pharmaceutical compositions, and method of use thereof
Daniel Levy, San Carlos, CA (US);
Charles Marlowe, Redwood City, CA (US);
Kim Kane-maguire, Belmont, CA (US);
Robert M. Scarborough, Half Moon Bay, CA (US);
Daniel Levy, San Carlos, CA (US);
Charles Marlowe, Redwood City, CA (US);
Kim Kane-Maguire, Belmont, CA (US);
Robert M. Scarborough, Half Moon Bay, CA (US);
Millennium Pharmaceuticals, Inc., Cambridge, MA (US);
Abstract
The present invention relates to derivatives and analogues of adenine of the formula:wherein L, A, Y and Z are those defined herein. Compounds of the present invention are useful in inhibiting adenylyl cyclase activity. The present invention also relates to a method of preventing and inhibiting a patient's fibroproliferative vasculopathy following vascular injury or a vascular surgical operation which includes administering to the patient, an effective amount of a compound according to the invention subsequent to a vascular injury, or subsequent to a vascular surgical operation, for one to two weeks after the injury or surgical operation, effective to treat or prevent a patient's fibroproliferative vasculopathy such as chronic allograft rejection or vascular restenosis following vascular trauma. The present invention also relates to a method for measuring the inhibition of adenylyl cyclase activity and a method for treating congestive heart failure.