The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 03, 2005
Filed:
Nov. 06, 2000
Gordon Craig Hill, Stockton, CA (US);
Stephen B. Kahl, Portola Valley, CA (US);
Robert R. Webb, Rancho Penasquitos, CA (US);
Constance A. Mckee, Woodside, CA (US);
Gordon Craig Hill, Stockton, CA (US);
Stephen B. Kahl, Portola Valley, CA (US);
Robert R. Webb, Rancho Penasquitos, CA (US);
Constance A. McKee, Woodside, CA (US);
Asilomar Pharmaceuticals, Inc., Woodside, CA (US);
Abstract
A method for improving intracellular administration of a therapeutic agent is provided comprising: contacting cells with a compound comprising a charged derivative of a therapeutic agent having a therapeutic activity, the charged derivative being conjugated to a protein having a biological activity of being transported across a cell membrane into a cell; and having the cell transport the compound into the cell where the cell metabolizes at least a portion of the compound to form a charged metabolite product that possesses the therapeutic activity of the therapeutic agent, the charged metabolite product being less prone to being transported across the cell membrane out of the cell relative to the compound and less prone to being transported across the cell membrane out of the cell relative to the therapeutic agent.