The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 03, 2005
Filed:
May. 25, 2001
Anthony L. Fitzhugh, Frederick, MD (US);
Peiwen Cheng, Santa Rosa, CA (US);
Joseph Saavedra, Thurmont, MD (US);
Robert Cafferata, Belmont, MA (US);
Marc Hendriks, Brunssum, NL;
Larry K. Keefer, Bethesda, MD (US);
Eugene Tedeschi, Santa Rosa, CA (US);
Michel I. P. M. Verhoeven, Maastricht, NL;
Anthony L. Fitzhugh, Frederick, MD (US);
Peiwen Cheng, Santa Rosa, CA (US);
Joseph Saavedra, Thurmont, MD (US);
Robert Cafferata, Belmont, MA (US);
Marc Hendriks, Brunssum, NL;
Larry K. Keefer, Bethesda, MD (US);
Eugene Tedeschi, Santa Rosa, CA (US);
Michel I. P. M. Verhoeven, Maastricht, NL;
Medtronic Vascular, Inc., Santa Rosa, CA (US);
The United States of America as represented by the Department of Health and Human Services, Washington, DC (US);
Abstract
Biocompatible metallic medical devices having silanized surfaces coupled to nucleophile residues that release sustained, therapeutic amounts of nitric oxide to specific sites within a mammalian body are provided. Additionally, the biocompatible metallic medical devices can also be provided with anti-thrombogenic, lubricious coatings that release sustained, therapeutic amounts of nitric oxide. Moreover, the silanized metallic devices are surprisingly durable when exposed to harsh chemical methods often needed to bind nitric oxide-releasing functional groups to nucleophile residues. Furthermore, methods are provided for producing stable, silanized, sustained nitric oxide-releasing metallic medical devices.