The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 03, 2005
Filed:
Sep. 07, 2000
Dominique P. Bridon, Outremont, CA;
Alan M. Ezrin, Moraga, CA (US);
Peter G. Milner, Los Altos Hills, CA (US);
Darren L. Holmes, Montreal, CA;
Karen Thibaudeau, Montreal, CA;
Dominique P. Bridon, Outremont, CA;
Alan M. Ezrin, Moraga, CA (US);
Peter G. Milner, Los Altos Hills, CA (US);
Darren L. Holmes, Montreal, CA;
Karen Thibaudeau, Montreal, CA;
Conjuchem, Inc., Montreal, CA;
Abstract
A method for protecting a peptide from peptidase activity in vivo, the peptide being composed of between 2 and 50 amino acids and having a C-terminus and an N-terminus and a C-terminus amino acid and an N-terminus amino acid is described. In the first step of the method, the peptide is modified by attaching a reactive group to the C-terminus amino acid, to the N-terminus amino acid, or to an amino acid located between the N-terminus and the C-terminus, such that the modified peptide is capable of forming a covalent bond in vivo with a reactive functionality on a blood component. In the next step, a covalent bond is formed between the reactive group and a reactive functionality on a blood component to form a peptide-blood component conjugate, thereby protecting said peptide from peptidase activity. The final step of the method involves the analyzing of the stability of the peptide-blood component conjugate to assess the protection of the peptide from peptidase activity.